2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125818C
    Cytidine-5'-triphosphate disodium hydrate 652154-13-7 98%
    Cytidine 5′-triphosphate is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate disodium hydrate
  • HY-125818I
    Cytidine-5'-triphosphate, 100mM Solution, PCR Grade 65-47-4 98%
    Cytidine-5'-triphosphate, 100 mM Solution, PCR Grade (Cytidine triphosphate, 100mM Solution, PCR Grade) Cytidine-5'-triphosphate solution is 100 mM and free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Cytidine-5'-triphosphate (HY-125818) is a nucleoside triphosphate that serves as a building block for the biosynthesis of nucleotides and nucleic acids and lipids. Cytidine triphosphate synthase can catalyze the conversion of UTP to 5'-CTP.
    Cytidine-5'-triphosphate, 100mM Solution, PCR Grade
  • HY-125857B
    Cytochrome C (Saccharomyces cerevisiae) 9007-43-6 98%
    Cytochrome C (Saccharomyces cerevisiae) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (Saccharomyces cerevisiae) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (Saccharomyces cerevisiae) can act as a single electron carrier.
    Cytochrome C (Saccharomyces cerevisiae)
  • HY-125863A
    Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) 9001-40-5 98%
    Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase.
    Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant)
  • HY-125863B
    Glucose 6-phosphate dehydrogenase (yeast, recombinant) 9001-40-5 98%
    Glucose 6-phosphate dehydrogenase (yeast, recombinant) is the rate-limiting enzyme of the pentose phosphate pathway and a major source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, and cytochrome P450 systems. Glucose 6-phosphate dehydrogenase helps cells resist oxidative stress and regulates metabolic rates. It holds potential for research in fields such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy.
    Glucose 6-phosphate dehydrogenase (yeast, recombinant)
  • HY-125954A
    Uridine diphosphate glucuronic acid ammonium 43195-60-4 98%
    Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum.
    Uridine diphosphate glucuronic acid ammonium
  • HY-125954B
    UDP-galacturonic acid trisodium 148407-07-2 98%
    UDP-galacturonic acid trisodium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase.
    UDP-galacturonic acid trisodium
  • HY-125954S
    Uridine diphosphate glucuronic acid-13C,15N2
    Uridine diphosphate glucuronic acid-13C,15N2 (UDP-α-D-glucuronic acid-13C,15N2) is the 13C- and 15N-labeled Uridine diphosphate glucuronic acid (HY-125954). Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum.
    Uridine diphosphate glucuronic acid-13C,15N2
  • HY-126042R
    (±)-Lisofylline (Standard) 6493-06-7
    (±)-Lisofylline (Standard) is the analytical standard of (±)-Lisofylline. This product is intended for research and analytical applications. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research.
    (±)-Lisofylline (Standard)
  • HY-126050R
    (R)-Pantetheine (Standard) 496-65-1
    (R)-Pantetheine (Standard) is the analytical standard of (R)-Pantetheine. This product is intended for research and analytical applications. (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity.
    (R)-Pantetheine (Standard)
  • HY-126198A
    Linogliride fumarate 78782-47-5 98%
    Linogliride (MCN-3935) fumarate is an antidiabetic agent. Linogliride fumarate (100 μM) does not affect insulin secretion in the absence of glucose, but has a significant insulinotropic effect in the presence of 5.5 mM glucose.
    Linogliride fumarate
  • HY-126995R
    Glycohyodeoxycholic acid (Standard) 13042-33-6
    Glycohyodeoxycholic acid (Standard) is the analytical standard of Glycohyodeoxycholic acid. This product is intended for research and analytical applications. Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation.
    Glycohyodeoxycholic acid (Standard)
  • HY-128394R
    L-Gulose (Standard) 6027-89-0
    (20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1. This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin.
    L-Gulose (Standard)
  • HY-128417S
    alpha-D-glucose-d12 1379594-94-1 98%
    alpha-D-glucose-d12 is the deuterium labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite.
    alpha-D-glucose-d12
  • HY-128426R
    Trans-?2-?butene-?1,?4-?dicarboxylic acid (Standard) 4436-74-2
    Trans-​2-​butene-​1,​4-​dicarboxylic acid (Standard) is the analytical standard of Trans-​2-​butene-​1,​4-​dicarboxylic acid. This product is intended for research and analytical applications. Trans-​2-​butene-​1,​4-​dicarboxylic acid (Dihydromuconic acid; trans-β-Hydromuconic acid) is an endogenous metabolite[1][2].
    Trans-?2-?butene-?1,?4-?dicarboxylic acid (Standard)
  • HY-128434R
    L-Leucyl-L-alanine (Standard) 7298-84-2
    L-​Leucyl-​L-​alanine (Standard) is the analytical standard of L-​Leucyl-​L-​alanine (HY-128434). This product is intended for research and analytical applications. L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine.
    L-Leucyl-L-alanine (Standard)
  • HY-128447R
    Allyl methyl sulfide (Standard) 10152-76-8
    Allyl methyl sulfide (Standard) is the analytical standard of Allyl methyl sulfide (HY-128447). This product is intended for research and analytical applications. Allyl methyl sulfide is an orally active organic sulfide. Allyl methyl sulfide is one of the main active ingredients in garlic volatile metabolites. Allyl methyl sulfide can be extracted from garlic. Allyl methyl sulfide enhances SOD activity, inhibits NF-κB signaling pathway, and upregulates pancreatic GLUT2 expression. Allyl methyl sulfide has significant antioxidant, anti-inflammatory and hypoglycemic activities. Allyl methyl sulfide can be used in the research of diabetes and its complications.
    Allyl methyl sulfide (Standard)
  • HY-128463S
    N-tert-Butyl-α-phenylnitrone-d14 119391-92-3 98%
    N-tert-Butyl-α-phenylnitrone-d14 is the deuterium labeled N-tert-Butyl-α-phenylnitrone. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier.
    N-tert-Butyl-α-phenylnitrone-d14
  • HY-128738R
    Thymidine-5'-monophosphate disodium salt (Standard) 33430-62-5
    Thymidine-5'-monophosphate (disodium) salt (Standard) is the analytical standard of Thymidine-5'-monophosphate (disodium) salt. This product is intended for research and analytical applications. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.
    Thymidine-5'-monophosphate disodium salt (Standard)
  • HY-128738S
    Thymidine-5'-monophosphate-13C10,15N2 disodium 1485539-28-3 98%
    Thymidine-5'-monophosphate-13C10,15N2 (disodium) is the 13C and 15N labeled Thymidine-5'-monophosphate disodium salt. Thymidine-5'-monophosphate disodium salt is an endogenous metabolite.
    Thymidine-5'-monophosphate-13C10,15N2 disodium
Cat. No. Product Name / Synonyms Application Reactivity